The regiment began as the 22nd Anti-Aircraft Artillery Division of the Red Army formed during World War II, which was reorganized as a brigade postwar.

On 7 September 1944 the 22nd was awarded the Order of Kutuzov, 2nd class for "exemplary fulfillment of command tasks" in breaking through enemy defenses south of Bender and the capture of Kishinev and its "valor and courage".

[6] The division, reinforced with tanks and infantry, acted as an assault group during the battle for Belgrade, participating in the capture of the royal palace, parliament building, post and telegraph office, and the military academy.

The division was awarded the Order of Bogdan Khmelnitsky, 2nd class, on 26 April 1945 in recognition of its performance in the capture of Pápa and Devecser.

[7] From 1943 to the end of the war, the division was credited with destroying 264 aircraft, up to 3 infantry regiments, capturing up to 10,000 soldiers and officers, knocking out 45 tanks, burning three railway echelons, and suppressing the fire of 15 batteries.

[9] The division was subsequently transferred to the Special Mechanized Army and renumbered as the 98th Anti-Aircraft Artillery Brigade in November 1955.

When air defense units were reorganized on 30 July 1960 due to the replacement of anti-aircraft guns by surface-to-air missiles, the division was reorganized as the 108th Anti-Aircraft Missile Brigade of the 1st Separate Army, a unit of the Air Defense of the Ground Forces.