[1] Since February 18, 2004, a platoon of the unit was deployed for peacekeeping operations in Wasit Governorate in Iraq, as well as in Sierra Leone, Liberia and other conflict zones.

[4] In 2013, the regiment also conducted training at the Havryshiv military airfield, near Vinnytsia which included an airborne assault with an An-26, capturing command posts amongst other objectives.

[10] On June 17, 2014, during the battle of Shchastya, personnel from the 8th special forces regiment were sent as reinforcement to relieve the Aidar Battalion under encirclement,[11] five special forces were wounded by separatist APC and RPG and one of the personnel Yevgeny Oleksandrovich Zelenskyi, died on June 24 from his wounds[12] and was posthumously awarded the Hero of Ukraine.

[13] On July 9, 2014, a KAMAZ vehicle of the regiment with 8 personnel was ambushed near the village of Muratove killing one soldier (Savanchuk Victor Yuriyovych) and wounding three others.

[15] Regiment personnel moved in two strike forces, one reached first and provided cover to the second, numbering 14 people[16] under the leadership of Petrakivskyi continued to advance.

The regiment's convoy had to be stopped and take up defense but their position was shelled by mortar, injuring a large number of soldiers including Oleksandr Petrakivskyi who was wounded in the head.

[19] On January 29, 2015, the 8th separate regiment captured Igla MANPADS, five MON-100 anti-personnel mines, PB suppressed handguns, Russian military uniform, machine guns and cartridges belonging to the separatists in the Luhansk Oblast.

[21][22] On February 10, 2015, a rocket attack by separatists on Kramatorsk Airport using BM-30 Smerch MLRS, led to the deaths of one soldier of the regiment (Yevhen Valeriyovych Bushnin) amongst others.

The Ukrainians temporarily retreated and then came back, to prevent further attack they carried out an operation during which a soldier (Roman Mykhailovych Matviets) died and three were wounded, meanwhile five more separatists were also killed.

[44] The regiment was involved in combat operations in the village of Verbove, Zaporizhzhia Oblast as a part of the 2023 Ukrainian Counteroffensive and a soldier of the unit (Atamanyuk Anton Mykhailovych) was killed in action on 15 October 2023.

[51] A soldier of the regiment, Vladyslav Alexandrovych Bombela died on 11 July 2024 in Donetsk Oblast after being seriously injured and was posthumously awarded the Hero of Ukraine.

[52] On 16 August 2024, during the 2024 Kursk offensive, the regiment published a video in which they ambushed a Russian truck, purportedly killing a dozen soldiers "in a few minutes".