The second government of José Luis Rodríguez Zapatero was formed on 14 April 2008, following the latter's election as Prime Minister of Spain by the Congress of Deputies on 11 April and his swearing-in on 12 April, as a result of the Spanish Socialist Workers' Party (PSOE) emerging as the largest parliamentary force at the 2008 Spanish general election.

[3][4] It was automatically dismissed on 21 November 2011 as a consequence of the 2011 general election, but remained in acting capacity until the next government was sworn in.

[19][20][21] From April 2009, the Council would include a third deputy prime minister.

[25] José Luis Rodríguez Zapatero's second government was organised into several superior and governing units, whose number, powers and hierarchical structure varied depending on the ministerial department.

[20][22][24] Deputy Prime Ministerfor Economic Affairs(Vicepresidencia del Gobiernode Asuntos Económicos)(from 12 July 2011) Deputy Prime Ministerfor Territorial Policy(Vicepresidencia del Gobiernode Política Territorial)(from 12 July 2011) Ministry of Education(Ministerio de Educación)(from 7 April 2009) Ministry of Territorial Policy(Ministerio de Política Territorial)(7 April 2009 – 21 October 2010) Ministry of Territorial Policyand Public Administration(Ministerio de Política Territorialy Administración Pública)(from 21 October 2010) Ministry of Healthand Social Policy(Ministerio de Sanidady Política Social)(7 April 2009 – 21 October 2010) Ministry of Health,Social Policy and Equality(Ministerio de Sanidad,Política Social e Igualdad)(from 21 October 2010)