The club was founded in 1962 and in the following years alternating between the D series championships, Eccellenza and Promozione.

In 2006–2007 Grottaglie for the first time in its history got into the qualifying play-offs for promotion, but it lost the first game to another team from Apulia, ASD Barletta.

The following season, it moved up to 5th place in the league, and again gained qualification for the playoffs, although the race ended at this juncture in the first round against ASD Barletta.

On 7 June 2009, Grottaglie lost 1–0 in an away match at Bitonto, after drawing 0–0 in the first leg, and moved back down to Eccellenza.

However, on 2 September 2009, Grottaglie returned to Serie D after the decision of the National Court of Arbitration for Sport to reassign the places in the league.