It currently plays in Serie D. The club was founded in 1920 as Gruppo Sportivo Pomigliano.

After several years in the regional championships in 1947 comes the first historic promotion to Serie C (under the name of Juve Alfa Pomigliano, enactment of working men's club soccer establishments in Alfa Romeo city), finished in ninth place but the structural reform of the championships send them in the Promozione.

After several years between the regional top flight and Serie D, due to various economic hardships that have arisen from the late eighties, the company finally disappeared in 1992.

Restarting from Terza Categoria, Pomigliano Calcio returned to Serie D in 2002, 15 years after the last inter-regional tournament played.

In the 2010–11 and 2011–12 seasons the club gained access to the promotion play-off for Lega Pro Seconda Divisione, but was eventually eliminated both times.