The club was established on 1 August 1951 under the name of A.S. Esperia (Esperia means "land of the West", name given by the ancient Greeks to the Italian peninsula for being located west of Greece, in the direction indicated by the Star Of Hope), with Mario Basso as president and headquarters in via Raffineria and pitch in Servola.

As members of the board of directors enter former players who give impetus to a new course in the youth sector.

On 12 June 1979 the club takes the name A.C. San Luigi For You and Paolo Cecada was elected president, who was replaced in 1982 by Ezio Peruzzo.

The club, in a few years, passes from the Terza Categoria to Promozione and Eccellenza and also to Serie D. Even the youth sector, which has over 200 young players, reaped successes.

The flagship is the conquest of a title of Italian champions obtained by the Juniores (under 18 years old) team in the 2003–04 season.