Guyton chose to play basketball for the Indiana University Hoosiers under coach Bob Knight from 1996 to 2000.

Guyton's first year saw him become only the second Hoosier freshman to collect 400 points, 100 steals and 100 assists; the other to pull that off is Isiah Thomas.

The end of his time at Indiana saw tumultuous changes when former Hoosier teammate Neil Reed went public with an accusation that Coach Knight had put a choke hold on him in practice three years before.

Calling a special press conference to give the players' point of view were Guyton and his four-year running mate at guard, Michael Lewis.

For him (Reed) to pick that time, our senior year, to come out and tell his story, it showed a lack of respect for our team.

[4] Guyton led the Flex, then known as the Central Illinois Drive, to a 22–1 record in 2012 and a Premier Basketball League championship.

Guyton also led the Flex to a PBL title in 2013, winning Coach of the Year honors both seasons.

In 2014, the Flex were again the top team in the PBL under Guyton's leadership, finishing the season with a perfect 18–0 record.

[5] On September 30, 2016, Guyton was appointed an assistant coach of the Windy City Bulls, a new NBA Development League franchise.