He was born in Tregnago in the Province of Verona and took a great interest in botany as a young man.
[1] Along with Gustav Wilhelm Körber, he founded the "Italian-Silesian" school of lichenology.
[3] He was the husband of Maria Colognato and the father of hepaticologist Caro Benigno Massalongo.
[5] In 1859 his Catalogo dei rettili delle province venete was published in Venice.
[1] He was honoured in 1855, when German lichenologist Gustav Wilhelm Körber circumscribed Massalongia which is a genus of lichen-forming fungi in the family Massalongiaceae.