The A63 autoroute is a motorway in southwest France, connecting Bordeaux (from Junction 15 of the Rocade) to the border with Spain and Basque Country via the Autopista AP-8.

The motorway, rather than being a purpose-built route, is an upgrade of the former RN10, which became a full toll road and no longer exists south of Bordeaux.

The A63 connects the border with Spain at Biriatou (close to Hendaye) at the southern edge of the Landes (department) towards Bordeaux which it reaches at junction 15 of rocade).

It is part of the Autoroute des Estuaires and is used by lorries from all over Europe heading to the Iberian Peninsula.

In addition, the road is connected at Bayonne with the A64 to Pau, Tarbes and Toulouse.