The broadcasting center, conceptualized by ABS-CBN's then-President Eugenio Lopez Jr., began construction on February 24, 1967 and was opened on December 18, 1968.

RPN and BBC, were all owned by Roberto Benedicto (a prominent crony of Marcos − along with IBC, in which Benedicto bought the network (including its flagship channel 13) from the Canoys, who owns RMN and the Sorianos (as Inter-Island Broadcasting Corporation) in 1975; and IBC which is still based from then town of San Juan del Monte, Rizal province (now city of San Juan, Metro Manila) at that time), and GTV was owned by the government through National Media Production Center (NMPC).

In 1980, the Bureau of Broadcasts (BB), a radio network also owned by the government under the Department/Ministry of Public Information, was also transferred to Broadcast Plaza from Philippine Communications Center (PHILCOMCEN) building (now demolished) in Ortigas Center, Pasig, Metro Manila after the Office of Media Affairs was created to provide a unitary form of media for both NMPC and the BB.

In 1986, the complex was stormed by anti-Marcos rebel soldiers that attacked and took over Channel 4 under the supervision of ABS-CBN's former General Manager Augusto Almeda-Lopez.

After Marcos was deposed and when Corazon Aquino became the first female president, on February 25, 1986, MBS was changed its interim name to The New TV-4 until it was officially rebranded as the People's Television Network (PTV) in April 1986 while the radio properties of NMPC and the BB were integrated to the reinstated pre-Martial Law era Philippine Broadcasting Service (PBS, through the Bureau of Broadcast Services or BBS).

The same year, RPN, IBC, and BBC were sequestered by the newly formed Presidential Commission on Good Government from Benedicto.

A marker in his memory on the spot where he died was erected a year after the assault, and Bohol Avenue, where ABS-CBN is situated, was eventually renamed Sgt.

At this point, the facility's former tenant RPN and its then-sister station IBC, once the dominant channels, both slumped in the ratings as ABS-CBN furthered its supremacy during the tail-end of the decade.

After past five years and four months of reopening on January 22, 1992, ABS-CBN finally regained full control of the facility after both PTV and the PBS/BBS moved out of the area to a new broadcasting complex (PIA/Government Information and Media Center Building) and the new 500 ft (150 m) transmitter tower situated in Visayas Avenue, Quezon City.

The building was built mainly to suit ABS-CBN's growing demands - a result of its diversification from a broadcasting network to a media powerhouse engaging not only in radio and TV broadcasting but now also in movie production, records, merchandising, cable and UHF TV, international services, and post-production.

[8][9][10][11][12] On March 7, 2023, reports said that the Broadcast Center will be demolished to be sold to ABS-CBN's sister company Rockwell Land Corporation.

[13][14] ABS-CBN and Rockwell Land Corporation later issued respective statements confirming that while it has been exploring the redevelopment of the Broadcast Center even before the COVID-19 pandemic, no agreement has yet been reached.

The statements were issued to clarify several erroneous news reports that the property has been sold to Rockwell Land for redevelopment.

The ten studios were built in 1968 and 2000 for the first seven and last three, respectively, and it is directly connected to the original building and ELJ Communications Center.

ABS-CBN Sports occupied the entire 7th floor before its Technical group was disbanded and its Production team moved to a room inside DZMM.

The building also housed the ABS-CBN Tulong Center, which was closed following the company's retrenchment program due to the non-broadcast franchise renewal.

[18] The building occupies ten thousand (10,000) square meters of land area and houses the network's offices, a studios, a three-level basement parking, a roof deck helipad, a film archive, a studio gallery, an exclusive executive dining restaurant, and garden.

The construction of the building, which costed 6 billion pesos, began in 1995, but was delayed due to the Asian Financial Crisis in 1997.

The dedication of the building was held on November 4, 2010, in a ceremony that was attended by the then-Philippine President Benigno Aquino III.