The club was founded on 1 July 1946 during Portuguese control and an affiliate of Atlético Lisbon.

[1] They played their first official competition in 1960, they played in what was the Portuguese Guinea Provincial Championships until full independence in 1974 (from 1973, also as the Guinea-Bissau Championships).

They played in the lower divisions, they came to play in the First Division from the 2002 season>[2] In cup competitions, the club reached the 2004–05 final against Sporting Clube de Bissau (the club also finished second in the league to Sporting Clube) and lost 4–2.

Bissorã had no appearance in the 2012 CAF Champions League due to financial concerns.

In 2012, journalist Maria da Conceição Évora became the first chairwoman of any football clubs in Guinea-Bissau.