The idea of AIIMS arose in 1946 by the prominent scientist Dr. Stotrom Das, after a recommendation by the Health Survey of the Government of India.

From then to the establishment and development of AIIMS (New Delhi) over the ensuing years, several illustrious individuals played their part in bringing the idea to fruition.

[5] On 18 February 1956, the then Minister of Health, Rajkumari Amrit Kaur, introduced a new bill in the Lok Sabha, that would eventually become the AIIMS Act.

It is adjacent to the South Extension-II market and lies on both sides of the Sri Aurobindo Marg, southwards to the AIIMS Roundabout flyover crossing.

The second campus of All India Institute of Medical Sciences (AIIMS-II), spread over 330 acres (1.335 square kilometres) of land was visualized during the period of Prof. Tirath Das Dogra as Director AIIMS Delhi and Anbumani Ramadoss (President, AIIMS), Minister of Health and Family welfare union of India in 2009 at Bhadsha village [also spelled Badsa] in Haryana's Jhajjar district.

AIIMS-II was thought to be developed as the largest medical Education centre for super-specialities in the world to meet the enormous need of super-specialists in various field in India.

The 330 acres of land was donated by the then Chief Minister Bhupinder Singh Hooda, of Haryana to Anbumani Ramadoss, in presence of Director AIIMS Tirath Das Dogra, in a big public function on 28 February 2009 at the proposed site.

[8] The next under the plan is a unique collaborative centre between IITD-Jhajjar campus located adjacent to the AIIMS (New Delhi)'s Jhajjar Extension.

[15][18][19][20] An intensive field practice area, the National Drug Dependence Treatment Centre[21] is an extension campus of AIIMS (New Delhi) in Ghaziabad city of Uttar Pradesh.

The Ex-Chief of the centre was a member of the International Narcotics Control Board (INCB), a monitoring body under the United Nations.

NDDTC has been designated as a WHO Collaborating Centre on Substance Abuse (2012–2020) In February 2019 The Union Cabinet chaired by Prime Minister of India has given 'in principle' approval to the Implementation of Master Plan to convert All India Institute of Medical Sciences (AIIMS), New Delhi into a world class Medical University.

[24] With senior faculty members raising issues of shortage of labs and operation theaters in the institute, the administration hopes the upcoming project will look into that concern.

(including casualty) (patients admitted) (operations/procedures) (43.5 lakhs+) (2.4 lakhs+) (1.9 lakhs+) AIIMS (New Delhi) was originally established as a super-specialty tertiary care centre with primary emphasis on research and specialized training facilities.

[30] As per the latest official notification released by the Ministry of Health and Family Welfare, AIIMS, JIPMER -Puducherry, PGI -Chandigarh & all INIs (Institutes of National Importance) were directed to not to conduct any Undergraduate entrance exams from 2020 onwards.

Many field experts however criticized this exam unification, specifically with respect to AIIMS (New Delhi), citing the reason that the level of questions in AIIMS-UG entrance exams (for both MBBS & BSc Nursing courses separately) used to be of such a higher & deep logical-conceptual thinking capabilities, that they eventually served a greater advantage for selecting the most desirable students for such scientific courses.

[38] AIIMS New Delhi was ranked 204th in the world and first in South Asia in the category of Life Sciences and Medicine by QS WUR in 2022.

[46] Opposition parties on basis of this investigative report and documents mentioned in the report, accused Nadda of links with senior IAS officer Vineet Chawdhry who had earlier worked with Nadda in Himachal Pradesh[47] On 23 November 2022, servers of AIIMS New Delhi were hacked by a ransomware attack after an employee opened a phishing mail.

A case of extortion and cyber terrorism was registered by the Intelligence Fusion and Strategic Operations (IFSO) unit of the Delhi Police on 25 November.