In each episode, members of AKB48 and occasionally their sister groups participate in activities that include quizzes, games, sports, and news.

The hosts of the show were changed in June 2016 after 395 episodes, when the owarai comedy duo Bad Boys, consisting of Kiyoto Ōmizo & Masaki Sata, were succeeded by Woman Rush Hour, consisting of Daisuke Muramoto & Paradise Nakagawa.

(AKB48のどっぼーん！ひとりじめ！), in which players can contribute points to support members of their choice, by the end of the month.

NEO was released on March 29, 2021 on the BS Nippon satellite television channel, again hosted by Woman Rush Hour.

Episode two was released on July 20, in which Muramoto announced that he would leave the show to move to the United States.

The final episode was released on December 29, featuring Paradise Nakagawa and the comedy trio Jungle Pocket as hosts.

In March 2022, it was announced that a new AKB48 variety show, titled AKB48 Sayonara Mōri-san, would start airing in April.

[4] It would be hosted by the comedy duo Shimofuri Myojo and former AKB48 member and AKBingo!

The show is telecast online every Friday starting from July 4, 2014, but the network sometimes offers some "sneak peeks", on Thursdays.