64577237320ENSG00000118514ENSMUSG00000037542Q9H2A2Q8BH00NM_001193480NM_022568NM_170771NM_178713NP_001180409NP_072090NP_739577NP_848828Aldehyde dehydrogenase 8 family, member A1 also known as ALDH8A1 is an enzyme that in humans is encoded by the ALDH8A1 gene.

It was originally thought to play a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo.

However, bioinformatics and experimental work has shown that it is more likely the aldehyde dehydrogenase of the kynurenine pathway, oxidizing 2-aminomuconate semialdehyde to 2-aminomuconic acid.

[6] Two transcript variants encoding distinct isoforms have been identified for this gene.

[7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.