In 1997, the Servants of the Holy Heart of Mary combined with the Franciscan Sisters of the Sacred Heart and Sisters of Mercy of Americas to form Provena Health, and the hospital name changed to Provena St. Mary's Hospital.

This merger allowed the hospital to expand its services and increase the level of complete health care.

[1] In 2021, AMITA Health was dissolved when AdventHealth and Ascension ended their joint venture.

In 2008, Presence St. Mary's Hospital completed a $2 million first-floor renovation project, for the purpose of enhancing patient comfort and care.

And in 2011, it became one of 94 hospitals in the United States to receive the American College of Cardiology Foundation's NCDR ACTION Registry–GWTG Silver Performance Achievement Award.