The league's season is divided into two tournaments called the Apertura and Clausura.

The Eastern Conference is composed by: Tauro, Plaza Amador, Alianza, Club Deportivo del Este, Arabe Unido, and Sporting San Miguelito, while the Western Conference is composed by: Herrera FC, Club Atletico Independiente, Veraguas, Club Universitario, Chiriqui, and San Francisco.

First Round of Playoff are 1 leg matches (2nd place team in each conference plays at Home).

The champions of both tournaments + the next best ranked team qualify to the CONCACAF Central American Cup.

In 1987, a group of men, composed of Giancarlo Gronchi, Jan Domburg, Edgar Plazas, Jorge Zelasny, Ángel Valero and Juan Carlos Delgado, met and founded the Asociación Nacional Pro-Fútbol (ANAPROF for short), which was inaugurated on February 26, 1988.

Following mediation by CONCACAF, on January 6, 1996, the leagues were unified under the ANAPROF name.

[2] Árabe Unido, Projusa (Veraguas), Chorrillo, Alianza FC, Internacional Puerto Armuelles, Tulihueca de La Chorrera, Corporación Deportiva Independiente Municipal Panamá (DIM), Vista Alegre, Cruz Azul (David, Chiriquí) y el Altamira - Cosmos, Árabe Unido, Projusa, Internacional Puerto Armuelles, Tulihueca de La Chorrera, Cosmos, Chorrillo, Alianza, Corporación Deportiva Independiente Municipal Panamá (DIM), Tigres de Vista Alegre y Cruz Azul.

The following table shows past results for ANAPROF (1988-09) and the Liga Panameña de Fútbol (2009–present) 1 Including 2 Winners in LINFUNA.