Mitchell's earliest public performances of "A Case of You" contain six lines that had changed by the time Blue was recorded.
The line "I am as constant as a northern star" is an allusion to Caesar's "I am constant as the Northern Star" from the Shakespeare play Julius Caesar, while the quoted line "Love is touching souls" is inspired by the German poet Rainer Maria Rilke.
lang covered the song on her 2004 album Hymns of the 49th Parallel, a tribute to her favourite Canadian songwriters.
Samples of the cover were then used in the tracks "Tep and the Logic" and "You Know Your Youth", which appeared on the deluxe edition of his eponymous debut album.
Other notable versions were performed by Rebekah Smarin (2014), Madi Davis (2015), Troy Ramey (2017), and Addison Agen (2017).
[14] The song appears in the films Truly, Madly, Deeply, Practical Magic, Clickbait (cover) and Waking the Dead.
[15] Truly, Madly, Deeply, writer-director Anthony Minghella's first film, marked the first appearance of "A Case of You" in a narrative film; the stars, Juliet Stevenson and Alan Rickman, sing the first verse and chorus of the song to each other, leading directly to the titular dialogue, "I truly, madly, deeply love you".
In 2013 the song was featured in "In Dreams Begin Responsibilities", the fourth episode of the fifth season of NBC's Parenthood.