Rina Satō stars as Misaka, the character she previously voiced from A Certain Magical Index (2008), alongside Satomi Arai, Aki Toyosaki, and Kanae Itō, with Atsushi Abe reprising his role as Toma Kamijo.

[3] In June 2009, Tatsuyuki Nagai joined the staff at J.C.Staff as the director, along with Seishi Minakami as the series composition writer and Yuichi Tanaka as the character animation designer.

[5] In June 2009, Satō, Arai, and Atsushi Abe were confirmed to be reprising their respective roles from A Certain Magical Index as Misaka, Shirai, and Kamijo, along with Aki Toyosaki as Kazari Uiharu and Kanae Itō as Ruiko Saten.

[10] Satō, Arai, Toyosaki, and Itō attended a stage event at Dengeki Character Festival 2009 [ja] in October to promote the series.

[25] Theron Martin of Anime News Network graded A Certain Scientific Railgun 'B', feeling that it was a "fun and engaging series that effectively mixes comedy, action, and some more serious elements and can stand plenty well on its own".

Despite praising the creative team for getting the right balance of humor, he criticized the music, "badly written" plots, and villain that was "stereotypically evil rather than anything more subtle".