A Lady Takes a Chance is a 1943 American romantic comedy film directed by William A. Seiter and starring Jean Arthur and John Wayne.

Written by Robert Ardrey and based on a story by Jo Swerling, the film is about a New York working girl who travels to the American West on a bus tour and meets and falls in love with a handsome rodeo cowboy.

[3] The supporting cast features Phil Silvers, Hans Conried, Charles Winninger and Mary Field.

Three of her suitors protest when Molly J. Truesdale, on a whim, boards a bus from New York City to discover the American West.

In a contemporary review for The New York Times, critic Theodore Strauss remarked that screenwriter Robert Ardrey "managed to brighten up an old formula until it looks almost brand new" and wrote: "If 'A Lady Takes a Chance' I is quite continuously amusing, it is largely because of Miss Arthur's pert little ways, her prim hesitations at the wrong times, her uncloying coyness.

"[5] The Film Daily's review was positive: "Smart, clever romantic comedy should prove a box-office wow.

"[6] Red Kann of Motion Picture Daily wrote: "If this is not on the riot side, it makes an unchallenged substitute.