Nancy (Loretta Young) and Jeff Troy (Brian Aherne) move into a somber-looking basement apartment building on 13 Gay Street, Greenwich Village, where the residents all act very strangely.

While eating in a nearby restaurant named Polly's Stable, Nancy overhears a man, later identified as Louis Kaufman, talking on the telephone telling someone to meet him in the basement apartment.

Jeff recognizes the basement apartment as a former speakeasy and reunites with the mascot of the old bar, a box turtle called "Old Hickory".

The suspects are Anne Carstairs (Jeff Donnell); her husband, Scott Carstairs (William Wright); Eddie Turner, the landlord; Polly Franklin (Lee Patrick), who owns Polly's Stable; Lingle (Richard Gaines), another resident; and the housekeeper, Mrs. Salter (Blanche Yurka).

"[1] Writing in DVD Talk, Jamie S. Rich described the film as "not as memorable as its title would have you believe," and although the "plot doesn't really add up to very much, Young is a joy to watch and it's all so light and fluffy, A Night to Remember ends up being pretty hard to hate.