A Plague Tale: Innocence is an action-adventure stealth game developed by Asobo Studio and published by Focus Home Interactive.

Set in mid-14th century Aquitaine, France, during the Hundred Years' War, the game focuses on the plight of Amicia de Rune and her ill brother Hugo as they flee from soldiers of the French Inquisition and from hordes of rats that are spreading the black plague.

The player controls Amicia, using a combination of stealth and limited tools to hide from, distract, or knock out soldiers, evade rat hordes, and solve puzzles, incorporating elements of survival horror games.

A Plague Tale: Innocence received generally positive reviews from critics and sold over one million units by July 2020.

For the majority of the game, the player needs to utilize stealth to avoid hostile encounters, as enemies will kill Amicia instantly if they catch her.

Amicia is equipped with a sling that can throw rocks to break chains, create distractions, or stun guards long enough for the rats to ambush them; she can also kill enemies with a headshot if their head is unprotected.

Amicia can craft special ammunition and supplies, which include fire-starting sulfur stones that ignite braziers, stink bombs that attract rats, or fire suppressants to extinguish torches carried by enemies.

In November 1348, Amicia de Rune is a 15-year-old French girl of noble descent who lives in Aquitaine during the Hundred Years' War between England and France.

[3] While hunting with her father Robert in the forest, Amicia encounters an unusual substance on the ground, and her dog Lion is gruesomely consumed by an unseen entity.

French Inquisition troops, led by Lord Nicholas, arrive at the de Rune estate in search of Hugo, executing Robert and slaughtering the family servants.

The two are wanted by the Inquisition and have to evade the villagers; Amicia and Hugo eventually reach Laurentius's farm and find him severely ill with the plague.

As they cross a battlefield patrolled by English soldiers, Lucas explains that Hugo's blood carries a supernatural evil called the Prima Macula, which has lain dormant within certain noble bloodlines since the Plague of Justinian.

Three days later, both the rats and the plague have disappeared and life begins to return to normal; many remain wary of Hugo and his power, including Mélie, who parts ways with the group.

[35] A sequel, titled A Plague Tale: Requiem, was released on 18 October 2022[47] for Nintendo Switch, PlayStation 5, Windows, and Xbox Series X/S.