The site's critical consensus reads: "Flat and unfocused, A Smile Like Yours aims for romantic comedy but settles for tired sitcom formula.

"[2] John Hartl of The Seattle Times criticized Samples for his direction and scripting of both his cast and comedic scenes coming across as flat and unfunny, saying that he "systematically takes each comic opportunity and drains the laughs out of it.

"[3] Lisa Alspector of the Chicago Reader felt that both Kinnear and Holly's characters were written to have charm and display "every clichéd behaviors" about their problems in a film that acts as an "incredibly naive attempt at schmaltz.

"[4] Dave Kehr, writing for the New York Daily News, said that despite both Kinnear and Hennessy's best efforts with the material given, the film suffers from "witless sex jokes", melodramatic tonal changes and lacking the sweetness found in the comedy Barefoot in the Park.

[5] Conversely, Kevin Thomas from the Los Angeles Times gave praise to the cast for their performances and both director Samples and co-writer Meyer for adding wit and "affectionate humor" to the film's infertility plot, despite having an unfulfilling conclusion, calling it "an uncommonly thoughtful and intelligent mainstream entertainment, painstaking and stylish in every aspect.