[3] Tshibola joined Reading's academy at age thirteen[4] and signed his first professional deal with the club in March 2011.

[9] On 2 January 2015, he moved to League Two side Hartlepool United on a one-month loan deal,[10] before making his debut the next day in a 1–0 loss against Wycombe Wanderers.

[17] On 27 July 2017, Tshibola joined EFL League One side Milton Keynes Dons on a season-long loan deal.

[20] Tshibola was loaned to Scottish Premiership club Kilmarnock in January 2018, working under his former Reading manager Steve Clarke.

[21][22] He made his debut for Killie on 3 February 2018, as a 65th minute substitute for Kris Boyd in the Ayrshire side's 1–0 win over Scottish Premiership Champions Celtic.

[28] On 13 July 2020, Tshibola announced on his Twitter account that due to financial difficulties at the club, he had left Aves and was a free agent once again.

[37] In August 2023, Tshibola joined newly promoted UAE Pro League team Hatta Club for a €150,000 fee.

[40] He was called up to the DR Congo national football team for a friendly against Kenya on 26 March 2017, but did not make an appearance.

[41] On 27 March 2018, he finally made his senior international debut for DR Congo, playing 45 minutes in a friendly against Tanzania.