[1][2] Writing primarily in Malay, Abdul Ghani produced a large body of poems, plays, short stories, and newspaper articles, further participating in more than 60 art exhibitions since 1950 with his abstract paintings.

[3][4] While studying at Raffles Institution, he sent poems and articles he had written to local Malay newspapers and magazines and held his inaugural art exhibition during a Youth Festival.

[3] After his studies, Abdul Ghani worked as an apprentice at the Electrical Department of Keppel Harbour, after which, he found a job as a clerk at the Public Utilities Board, then known as the Singapore Municipality.

[4][8] In 1956, the Angkatan Pelukis Muda (Young Artists' Movement) was founded and headed by Abdul Ghani, though it would be quickly dissolved after it was unable to gather enough support.

[8] In 1962, he co-founded the Angkatan Pelukis Aneka Daya (APAD, Artists of Various Resources) alongside Muhammad Ali Sabran, S. Mohdir, Ahmin Haji Noh, Hamidah M. F. Suhaimi and Mustafa Yassin.

[8] He was awarded the Anugerah Tun Sri Lanang by the Majlis Bahasa Melayu Singapura (Singapore Malay Language Council) in 1998, also receiving the S.E.A.

[10] Abdul Ghani continued to explore abstractions that made “allusions to the empirical”, for instance, in his 1973 painting Billet-Doux (Surat Cinta).