In 1930, he worked with Subhas Chandra Bose to carry out aid operations after a flood in North Bengal.

In 1946, Abdul Monem Khan organized the Muslim National Guard in Mymensingh with 100,000 volunteers and became the Salar-i-Zilla or the commander-in-chief of the district.

He was elected to the Constituent Assembly of Pakistan and East Bengal Primary Education Board in 1948.

He joined the cabinet led by President Ayub Khan becoming the Minister for Health, Labour and Social Welfare.

[2] Under the pressure of the 1969 mass student uprising, he was removed and replaced by Mirza Nurul Huda as the new governor on 24 March 1969.

[7] On 13 October 1971, he was shot at his Banani residence by a Mukti Bahini member named Mozammel Hoque.

[9] In November 2016, Dhaka North City Corporation demolished structures on a land in Banani occupied, as per the order of the then mayor Annisul Huq, for over five decades by the family of Khan.

[13] It was established at his house at Notun Bazar Saheb Ali Road in Mymensingh town in 1996.