Abe Masatsugu (阿部 正次, 1569 – December 10, 1647) was a daimyō in early Edo period, Japan.
In 1619, following the disgrace of the Ōkubo clan, he was reassigned to Odawara Domain (50,000 koku) in Sagami Province.
In 1623, he was reassigned, this time to Iwatsuki Domain (55,000 koku) in Mutsu Province, where his descendants remained for the next several generations.
In 1626, he was appointed Osaka-jō dai, a position which he held for the next 22 years until his death, and which raised his revenues to 86,000 koku.
Msatsugu died in Osaka in 1647; his grave is at the temple of Zōjō-ji at Shiba in Tokyo.