[2] After beginning graduate studies in the lab of Justin DuBois at Stanford University, Doyle completed her Ph.D. under Prof. Eric N. Jacobsen, where she developed enantioselective alkylations with tributyltin enolates catalyzed by a Cr(salen)Cl catalyst.
[6] In 2021, she moved to the University of California, Los Angeles, where she holds the Saul Winstein Chair in Organic Chemistry.
In collaboration with David MacMillan's group, the Doyle lab identified a new cross-coupling paradigm which allows the combination of photoredox and nickel catalysis.
The group has also been involved in the development of nucleophilic fluorination chemistry allowing the creation of pharmaceutically relevant molecules with sp3-C-F and sp2-C-F bonds.
These methods have employed both transition metal and photoredox catalysis, and the group has developed new reagents for mild and selective deoxyfluorination reactions.