In October 2020, United Express began daily flights to Houston-Intercontinental, operated by SkyWest Airlines.

Charter air carriers, such as Sun Country Airlines, continue to operate flights on an occasional basis from Abilene to Las Vegas with mainline jet aircraft, such as the Boeing 737.

primarily truck their overnight packages in from Dallas-Fort Worth, and most Abilene-bound FedEx Express shipments are sent through Lubbock.

Native Air (formerly Southwest Medevac) housed an emergency medical helicopter and crew at the airport for about 10 years, but closed the base in 2014.

Texas State Technical College provides aviation maintenance training at its on-field hangar base.

[6] American's 12-passenger Curtiss Condors had sleeper berths and flew Dallas Love Field - Ft. Worth - Abilene - Big Spring, TX - El Paso - Douglas, AZ - Tucson - Phoenix - Los Angeles.

[6] In the 1940s, American's Douglas DC-3s flew Dallas Love Field - Abilene - Big Spring - El Paso - Tucson - Phoenix - San Diego - Los Angeles.

Starting in the 1940s, Pioneer Air Lines Douglas DC-3s and Martin 2-0-2s flew to Dallas Love Field, Houston Hobby Airport, Albuquerque, Fort Worth, Amarillo, Lubbock and other cities in Texas and New Mexico.

[14] TTa flew nonstop to Austin and Lubbock and direct to Albuquerque, Amarillo, Houston Hobby Airport, San Antonio and Santa Fe.

TI served Amarillo and Lubbock from Abilene, and DC-9s flew to Dallas Love Field and to Dallas/Fort Worth Airport (DFW) after it opened.

[17] With the merger of Texas International and Continental Airlines, TI left Abilene and the airport lost its only jet service in the early 1980s.

[18] Jet service returned in 1984 when the original Frontier Airlines (1950-1986) began flying Boeing 737-200s direct to Denver via Midland/Odessa.

The upper-level houses the airline ticket counters, restaurant, gift shop, airport offices, and two departure gates, each with Jetway boarding bridges.

In the year ending May 31, 2023, the airport had 41,459 aircraft operations, an average of 114 per day: 54% general aviation, 29% military, 14% air taxi and 3% scheduled commercial.