They were assigned to be in the eighth company of missionaries to Hawaii for the American Board of Commissioners for Foreign Missions.

The Wilcoxes taught at the Hilo Mission boarding school founded by David Belden Lyman and his wife on the Island of Hawaiʻi.

In 1846 the family moved to teach at a similar school at the Waiʻoli Mission near Hanalei, Hawaii, on the northern coast of the island of Kauaʻi.

[4] Children were: In 1912 Sam, George, and Albert Wilcox donated funds for a new church at Waiʻoli, and the old one was converted to a hall.

[12] He was no relation to Robert William Wilcox (1855–1903) who was a military commander in several rebellions and then first delegate to US Congress from Hawaii.