[1][2][3][4] It resulted from a drift in the leaders of Eastern Christianity toward Miaphysitism and Emperor Zeno's unsuccessful attempt to reconcile the parties with the Henotikon.
In the events leading up to the schism, Pope Felix III wrote two letters, one to Emperor Zeno and one to Patriarch Acacius of Constantinople, reminding them of the need to defend the faith without compromise, as they had done previously.
The legates who brought these letters to Constantinople were imprisoned as soon as they landed and forced to receive communion from Acacius as part of a liturgy in which they heard Peter Mongus and other Miaphysites named in the diptychs.
Felix, having heard of this from the Acoemetae monks in Constantinople, held a synod in 484 in which he denounced his legates and deposed and excommunicated Acacius.
After Anastasius' death, his successor Justin I immediately sought to end the schism with Rome, a goal shared by the new Patriarch of Constantinople, John of Cappadocia.