The first accounts of the Hacarygua territory was in the writings of German colonizer Nicolás Federmann, who arrived in one of the area's indigenous villages on December 15, 1530.

He was headed to southwestern Llanos territory to search for the mythical city of El Dorado.

In the winter of 1535, German colonizer Jorge Spira sought shelter and food during his travels in what is now Acarigua.

The Thysania agrippina is one of the world's largest moths, with wings 32 centimetres (13 in) in size, and can be found in Acarigua.

Acarigua is served by the Oswaldo Guevara Mujica Airport and the Central Western Railway System.