Acclamation began his third season with four races on the synthetic Cushion Track at Santa Anita, producing his best effort when finishing third to Jeranimo in the Strub Stakes on 13 February.
[7] He then moved back to the turf track at Hollywood and finished fourth in the Grade III Inglewood Handicap on April 26.
On May 15, Acclamation, ridden by Christian Santiago Reyes started a 14.5/1 outsider for the Grade 2 Jim Murray Handicap over one and a half miles at the same course.
He took the lead soon after the start, opened up a clear advantage and won by a race record margin of seven and a half lengths from Falcon Rock.
[8] On June 6, the horse was moved up in class to contest the Grade I Charles Whittingham Memorial Handicap over a mile and a quarter.
[10] Acclamation ran poorly in his two remaining races in 2010, finishing last of nine behind Chinchon in the United Nations Stakes and sixth of seven behind The Usual Q. T. in the Eddie Read Handicap.
Joel Rosario took over the ride when Acclamation returned to turf and attempted to repeat his 2010 success in the Jim Murray Handicap.
Acclamation took the lead from the start and set a steady pace before accelerating at halfway and drawing away to win by three and a quarter length from Jeranimo.
He held off the strong challenge of Twirling Candy in the straight to in by a head, with the pair finishing four lengths clear of the other runners.
[21] On June 10 he took the Charles Wittingham for a third straight year, leading from the start and winning by a length from the San Marcos Handicap winner Slim Shadey, to whom he was conceding four pounds.
On July 21, the horse repeated his 2011 success in the Eddie Read, making all the running and winning by two and three quarter lengths from the Argentinian import Interaction.