The Acho Dene Koe First Nation is a Dene band government based in Fort Liard, Northwest Territories, Canada.

Its main community is the Hamlet of Fort Liard.

Acho Dene Koe First Nation has an existing treaty land claim settlement with the Governments of Canada, Northwest Territories, Yukon and British Columbia.

Registered population is 715, 164 of whom live off-reserve.

As of May 2017, Gene Hope was elected as Chief.