[2] The river has a course of about 142 kilometres (88 mi), and its waters irrigate the most populous sections[2] of the Chilean provinces of San Felipe de Aconcagua and Los Andes, being the most important economic resource of those regions.

The Aconcagua River valley was used as the route of the Transandine Railway on the Chilean side.

The river flows alongside Chile Route 5 from Llaillay to La Calera.

For much of their lengths, the two separate stretches of Chile Route 60 follow the course of the river.

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