[9] Northern monkshood is a perennial and can reproduce sexually by pollination or vegetatively by producing bulbils.

[10] The genus contains highly toxic alkaloids that act as cardiotoxins or neurotoxins (aconitine).

[11][4] The upper sepal of the flower is helmet shaped, and the two true petals are contained within the hood.

"[11] Northern monkshood was considered a disjunct population of Aconitum columbianum due to its morphological similarities.

[12] Genetic characterization of Aconitum noveboracense demonstrates similarity to A. columbianum populations located in western North America.

[12] Most populations of Northern Monkshood plant are found in northeastern Ohio, and portions of the "Driftless Area" located in northeast Iowa and southwest Wisconsin.

[7] Outflow of cool air and water from ice in underground fissures causes these conditions on algific talus slopes.

[9][7] Rising temperatures due to climate change endanger the sensitive environmental conditions required by A. noveboracense.

Fish and Wildlife Service developed a species recovery plan that describes actions needed to help the plant survive.

[9] The recovery plan outlined in 1978 also lists searching for new populations and further research into propagation of the plant as desired steps for its protection.