The Adam-Derby House is a notable 19th-century house, designed in the Queen Anne style, located at 166 Lexington Avenue in Oyster Bay, Nassau County, New York.

It was built in 1878 and designed by architects William Appleton Potter (1842-1909) and Robert Henderson Robertson (1849-1919) during their partnership as Potter & Robertson.

It is a 2+1⁄2- to 3-story dwelling with a wood exterior resting on a brick foundation in the Queen Anne style.

It features a variety of exterior detailing and turned post supports supporting the bracketed roofs of the verandahs, porches, and porte cochere.

This article about a historic property or district in Nassau County, New York, that is listed on the National Register of Historic Places, is a stub.