In the 2010s, Brody had supporting roles in comedies including Seeking a Friend for the End of the World (2012) and Sleeping with Other People (2015), and dramatic films such as Lovelace (2013).

For his performance as a rabbi in the Netflix romantic comedy series Nobody Wants This (2024), he earned a nomination for a Golden Globe Award for Best Actor.

[2] After a year of training and auditioning, Brody landed the role of Barry Williams in the television film Growing Up Brady (2000) and appeared in the Canadian comedy series The Sausage Factory.

[citation needed] In 2003, Brody appeared in the movie Grind and the music video for "Too Bad About Your Girl" by the Donnas.

That year, he was cast in his breakout role as Seth Cohen on the teen drama series The O.C., where he reportedly improvised some of the character's comedic dialogue.

[11] His next film role was in the romantic comedy In the Land of Women (2007), as a writer who returns to his mother's Michigan hometown to take care of his sick grandmother.

[11] In 2009, he starred in Boaz Yakin's drama Death in Love and in Diablo Cody's horror film Jennifer's Body.

[26] In 2024, he co-starred in the first season of Netflix’s Nobody Wants This as Rabbi Noah Roklov who starts dating Kristen Bell’s character, Joanne, a shiksa.

His performance earned him a nomination for the Golden Globe Award for Best Actor – Television Series Musical or Comedy.

The four-piece indie band played gigs at pubs and festivals from 2005 to 2007 such as The Knitting Factory, Bamboozle Left, The Roxy, Spaceland, and The Viper Room.

[30][31] In 2007, Brody, with Danny Bilson and Paul De Meo, co-wrote a comic-book miniseries for DC's Wildstorm Comics titled Red Menace.

Since 2010, Brody has played drums in the project band The Shortcoats; they released their first EP, This Time Last Year, on October 4, 2011.

Their song "Morning, Shipwreck," which Brody co-wrote, is featured in the sitcom Ben and Kate and the 2015 film The Meddler.