[2] The cathedral chapter of Würzburg Cathedral unanimously elected him Prince-Bishop of Würzburg on 7 January 1755, with Pope Benedict XIV confirming his appointment on 17 March 1755.
[2] He was consecrated as a bishop by Cardinal Franz Christoph von Hutten zu Stolzenfels, Prince-Bishop of Speyer, on 15 June 1755.
[2] At the insistence of Francis I, Holy Roman Emperor, he was elected Prince-Bishop of Bamberg on 21 April 1757, thus creating a personal union between the Prince-Bishopric of Würzburg and the Prince-Bishopric of Bamberg.
[2] Adam Friedrich von Seinsheim supported the imperial side during the Seven Years' War.
[1] Troops from the Kingdom of Prussia invaded both bishoprics during the course of this war.