Keighran signed a two-year deal in 2017 with the Penrith Panthers, kicking 80 goals for their New South Wales Cup side in 2018 and was picked as one of two Centres of the year despite playing the last 10 games of his season in the halves.

Keighran made his first grade debut in round 1 of the 2019 NRL season playing for the Warriors against the Canterbury-Bankstown Bulldogs, scoring a try in their 40–6 win.

Keighran became the second player in Super League history to be sin binned during a grand final after he was sent from the field for a dangerous lifting tackle in the first half.

[16] In round 13, Keighran was given a straight red card for a dangerous high tackle during Wigan's 19-18 victory over Warrington and subsequently missed the Challenge Cup final.

[17] On 12 October, Keighran played in Wigan's 9-2 2024 Super League grand final victory over Hull Kingston Rovers.