[6] On April 4, 2013, Lowry concluded his major junior career by signing an amateur tryout contract with the St. John's IceCaps of the American Hockey League (AHL).

[11] Lowry was promoted to the Winnipeg Jets for the 2014–15 season where he played on their third line alongside Mathieu Perreault and Dustin Byfuglien.

[12] Upon joining the team, Lowry scored his first career NHL goal on October 21 to help the Jets beat the Carolina Hurricanes 3–1.

[13] His linemates changed throughout the season and by January 2015, he was playing alongside Evander Kane and Chris Thorburn who helped him register six goals and 15 points through 48 games.

[17] Upon re-joining the Jets for his second season, head coach Paul Maurice experimented with Lowry on the first line alongside Andrew Ladd and Bryan Little in an attempt to spread out the offense.

[18] By December, he had recorded eight points and 22 penalty minutes through 31 games and was reassigned to the Jets' new AHL affiliate, the Manitoba Moose.

[19] After tallying four points in four games with the Moose, Lowry was recalled to the NHL level following the placement of Mark Scheifele on injured reserve.

[20] He rejoined the Jets' lineup for their game against the Pittsburgh Penguins and played 16 minutes and 52 seconds of ice time alongside Ladd and Alexander Burmistrov.

He finished the season averaging over two-and-a-half minutes of shorthanded ice time per game to lead all forwards in that category.

[30] He re-joined the team prior to their opening night game and participated in line rushes between Joel Armia and Brandon Tanev.

Lowry continued his face-off streak in Game 1 and won three straight draws to help the Jets protect their one-goal lead.

[45] Upon returning from his suspension, Lowry helped lead the Jets to an 8–1 win over the Hurricanes and clinch first place in the Central Division.

[46] Lowry's nine goals by March 24, helped the Jets qualify for their second-consecutive Stanley Cup playoffs for the first time in franchise history.

[47] When the Jets met with the St. Louis Blues in the first round, Lowry was placed on the fourth line with Pär Lindholm and Jack Roslovic as his wingers.

[50] Once the 2019–20 season arrived, Lowry was placed on a new line alongside Gabriel Bourque and Mark Letestu which was more defensively minded.

[53] Upon returning from his suspension, Lowry played 11:50 minutes of ice time and recorded three shots on goal in an eventual 4–3 overtime win over the Vegas Golden Knights.

[54] As a result of injuries to the Jets' lineup in late December, Lowry's line changed again and he played alongside Bourque and Mason Appleton.