Although he began as a rock musician playing in a number of bands (such as Mute) formed with his schoolmates, Pascal became drawn to musical theater.

[14] In January 2009, he and Rapp reprised their originating (and film) roles as Roger and Mark in Rent: The Broadway Tour, which played in many cities in North America, as well as stops in Japan and South Korea.

At the tour's Detroit, Michigan stop in February, Pascal suffered two herniated discs in his neck and was on medical leave for a week.

His role was filled in by Cary Shields, who had played "Roger" in the Broadway, Canadian, "Benny" National Tour productions.

[15] Pascal reprised the role of Frederick Trumper, aka "Freddie, The American" in the London concert version of Chess at the Royal Albert Hall on May 12–13, 2008.

[21] In late 2021, Pascal began performances as Edward Lewis in the U.S national tour of Pretty Woman: The Musical, a role which he had played on Broadway from January 15 to 20, 2019.

Pascal was cast as Ryuk in the English premiere of Death Note: the Musical for its concert run at the London Palladium[22] in August 2023.

[32] In School of Rock, he played Theo, lead singer of the band No Vacancy, and sang on two songs on the soundtrack.

The two musicians began composing and performing original material and reworked Broadway songs in small venues throughout the US.

As of 2009 and later,[update] Pascal is developing a theatrical stage version of the classic 1988 concept album, Operation: Mindcrime by the progressive metal band, Queensrÿche.

In late 2005, he, along with five others of the principal cast, reprised their roles in the film version of Rent, directed by Chris Columbus.

Pop idol Justin Timberlake was considered for the role of Roger,[36] but Columbus decided to stick with the original cast members.

His co-stars are Amy Davidson, Cris Judd, Tovah Feldshuh, Dean Edwards, Tibor Feldman, and Natasha Lyonne.

[37] Pascal also filmed another independent movie, Wild About Harry, about a gay couple who try to hide their relationship from family and neighbors in 1973, a few years following the Stonewall Riots.

[39] Pascal provided the narration and sang a song, "I'm Not an Egg Anymore", in the double-length episode "Tale of the Mighty Knights" for the show The Backyardigans.