James and Jessie N. Hughes House, is a historic building located in Mount Vernon, Iowa, United States.

[2] Adams and Frederick Knott were brothers who were originally from Ohio and they settled in Mount Vernon in 1854 after living briefly in other locations in eastern Iowa.

They bought a building and dry goods store from Oliver Day, an early pioneer merchant.

The two-story, side-gabled brick house features Early Republic stylistic influences.

This article about a property in Linn County, Iowa on the National Register of Historic Places is a stub.