The Adana–Mersin Main Line is a 67 km (41 miles) long double track rail line from the Adana Railway Station in Adana to the Mersin Railway Station in Mersin.

[1] At Yenice, between Tarsus and Adana, the main railroad line north to Ulukışla to the north joins the Adana–Mersin line; at Ulukışla, its two branches continue to Konya and Ankara to the northwest and Kayseri to the northeast.

On January 20, 1883, the Ottoman Government gave a concession to develop railways in Cilicia to two Turkish men.

In 1896, the Turkish men sold all their rights to the company, making the MTA fully foreign owned.

On January 1, 1929, the line was nationalized, as were the Chemins de Fer Ottomans d'Anatolie (CFOA).