Despite limited running training due to being a member of the soccer team, Wiley achieved All-State by placing 10th at the state championships in 18:28.6.

[3] Wiley was unable to defend her 1600m state championship title in spring of her sophomore year due to the COVID-19 pandemic.

In the fall of her junior year, Wiley achieved All-State status in cross country again by placing 6th with a time of 18:25.9.

[4] On March 26 & 28, Wiley competed in the NSAF USA Meet of Champions in Myrtle Beach, South Carolina where she won the mile in 4:48.23 and placed second in the 5000m in 17:16.15.

[6][7] She was subsequently named the 2020–2021 Gatorade Player of the Year award winner for Indiana Girls Track and Field.

[11] [12] Wiley ended her track season on July 3 at the Nike Outdoor National Championships at historic Hayward Field in Eugene, Oregon.

Wiley opened her senior track season on March 12 at Nike Indoor Nationals at the Ocean Breeze Athletic Complex on Staten Island, New York.

Her placing earned her a spot on the United States team that would compete in the World Athletics U20 Championships the following month.

At the 2022 NAIA Cross Country Championships held in Apalachee Regional Park in Tallahassee, Florida, Wiley finished in second place to earn her first collegiate All-America honor with a time of 16:58.9.

In a field consisting of 10 professional runners and only two collegiates, Wiley led the race for the first 1200m before ultimately placing 4th with a time of 4:18.84.

[30] Only 13 female athletes in NAIA history have won five or more indoor titles in a four-year career; Wiley accomplished it in less than four hours.

She suffered her only loss of the year to a collegiate runner in a track final, losing to Canadian Simone Plourde of the University of Utah.

The time broke the meet record of 4:03.64 set by 2021 Olympian Cory McGee and also met the World Athletics Championships standard of 4:03.50.

On July 6, Wiley won her semi-final heat with a time of 4:09.53, finishing ahead of 2021 Olympic gold medalist Athing Mu and Olympian Cory McGee.

[41] As a result of her placing, Wiley earned a spot on the United States team that would participate in the NACAC U23 Championships later that month but had to decline another $2,000 prize.

On July 23, Wiley represented the United States in the NACAC U23 Championships in San José, Costa Rica.

Competing in the 1500m, she won the gold medal and set a new meet record with a time of 4:05.84, her third sub-4:06 performance since the start of June.

She defeated a professional field that included 2023 World Championship team member Kaela Edwards to win in a personal record of 1:59.00, the fastest collegiate time in the nation in 2023.

[46] In September, Wiley made her first appearance on the European track circuit at the Galà dei Castelli meet in Bellinzona, Switzerland.

She placed 2nd to Jamaica's Natoya Goule with a new PR of 1:57.64, making her the second fastest collegiate 800m runner of all-time behind only Olympic gold medalist Athing Mu.

[47] On September 8, Wiley competed in her first Diamond League event, the Memorial Van Damme in Brussels, Belgium.

[48] Wiley represented the United States at the World Road Mile Championships in Riga, Latvia on October 1.

[50] On January 9, Wiley was named to the 2024 Bowerman Preseason Watch List, becoming the first NAIA athlete to ever receive the honor.

[51] On January 23, 2024, Wiley announced that she had signed a professional contract with Adidas and would forgo her final three seasons at Huntington University.

[52] Three days later, she made her professional debut at the PNC Lenny Lyles Invitational at the University of Louisville where she won the 800m.

Unfortunately, a bout of food poisoning sent her to the hospital and shortly afterward she injured her hamstring, forcing her to miss a lot of training in the weeks before the Trials.

On August 31, Wiley set her first American Record while competing in the Mityng Ambasadorów Białostockiego i Podlaskiego Sportu meet in Białystok, Poland.

[58] The tennis ball sized tumor was pressing on her lung and causing high fevers, extreme fatigue and headaches.

[59][60] In September 2023, in conjunction with her first track meets on the European circuit and Childhood Cancer Awareness Month, Wiley announced a fundraiser for patients at Riley Hospital for Children in Indianapolis, the hospital where she received her life saving cancer treatments ten years earlier.