Аdelchi Serena (27 December 1895 – 29 January 1970) was an Italian government official and fascist politician.

In 1915, he volunteered for the Royal Italian Army and participated in World War I, and was awarded a medal for military prowess.

From 1933 to 1939, he was deputy to Achille Starace, national secretary of the PNF.

On 30 October 1940, he succeeded Ettore Muti as national secretary of the PNF.

After the fall of the Fascist regime in Italy on 25 July 1943, he left politics and withdrew to private life.