As the director of the Baltimore Museum of Art, Breeskin established a works on paper collection, supervised an exhibit of John Russell Pope, mounted the show “Abstract Expressionism,” oversaw expansion to the institution, acted as commissioner for the American Contingent of 30th Venice Biennale, and negotiated the donation of Etta and Claribel Cone Collection.
From 1960 to 1974, she served as the curator of contemporary painting and sculpture at the National Collection of Fine Arts later called the National Museum of American Art where she featured artists such as Mary Cassatt, Milton Avery, H. Lyman Sayen, William J. Johnson, and Bob Thompson.
[2] In 1972, Dohme signed her name to the Ms. campaign: “We Have Had Abortions” which called for an end to "archaic laws" limiting reproductive freedom, they encouraged women to share their stories and take action.
She acted as curator of the Cassatt retrospective exhibition at the National Gallery of Art in 1970 though she was simultaneously working on the Sayn and Johnson shows.
Several hours a week, Breeskin devoted time to adding information to her catalogues and answering numerous questions from collectors from around the world.