This was Ronstadt's final studio album before her retirement in 2011 and the revelation of her affliction with Parkinson's disease (later revealed to actually be progressive supranuclear palsy) in 2013, leaving her unable to perform or sing.

Ronstadt, a soprano, and Savoy, an alto, had previously recorded duets for the Savoy-produced album Evangeline Made: A Tribute to Cajun Music; here, they sing together as The Zozo Sisters on the album, which brings together a mixture of Louisiana Cajun sounds, popular music of the 20th century, and folk/rock classics.

On her collaboration with Savoy, Ronstadt remarked: "We could have made a quilt, I guess, except we're musicians, so we're making a record together instead.

It features local musicians, including Chas Justus, Eric Frey and Kevin Wimmer of the Red Stick Ramblers, Sam Broussard of The Mamou Playboys, Dirk Powell and Joel Savoy, as well as Nashville performers, like fiddler Stuart Duncan, mandolinist Sam Bush and guitarist Bryan Sutton.

The Ronstadt/Savoy album received good reviews and landed on several year-end Top Ten lists.