The Adirondack Cottage Sanitarium was a tuberculosis sanatorium established in Saranac Lake, New York in 1885 by Dr. Edward Livingston Trudeau.

During his late teens, his elder brother James contracted tuberculosis and Edward nursed him until his death three months later.

In 1882, Trudeau read about Prussian Dr. Hermann Brehmer's success treating tuberculosis with the "rest cure" in cold, clear mountain air.

They were treated in a one-room cottage named "Little Red", built for $350 on land donated by the guides and residents of the village.

Patients included authors Allan Seager, Canadian physician and medical innovator Norman Bethune,[3] and baseball players Larry Doyle[4] and Christy Mathewson.