[3] Andoh grew up in Wickwar in Gloucestershire, where her family moved after her father got a job with British Aerospace.

[3][4] She attended Katharine Lady Berkeley's School and then started studying law at Bristol Polytechnic, but left after two years to pursue an acting career.

She played Chief of Staff Brenda Mazibuko opposite Morgan Freeman's Nelson Mandela in Clint Eastwood's 2009 drama film Invictus.

She has appeared in Doctor Who a number of times: in 2006 as Sister Jatt in series 2 episode "New Earth" and as Nurse Albertine in the audio drama Year of the Pig.

She played the guest role of Mother Nenneke in the second season of the Polish - American fantasy drama streaming television series The Witcher (2021).

In April 2023, The Real Crown: Inside the House of Windsor, an ITV television documentary series on the British royal family, aired.

[7] In 2021, it was announced that she was working with Bridgerton producer Julie Anne Robinson on a version of Vanessa Riley's novel, The Island Queen, for television.

1 Ladies' Detective Agency series of detective novels and Ann Leckie's Imperial Radch Series trilogy (although not all of the US editions), as well as Julia Jarman's children's books, The Jessame Stories and More Jessame Stories.

She also narrated the audio book version of Nnedi Okorafor's novel Lagoon with Ben Onwukwe,[12] and Chimamanda Ngozi Adichie's Americanah.

In 2020, it was announced that Andoh would direct Lettie Precious' Nina Simone's Four Negro Women as part of the Written on the Waves audio project.

[14] Penguin Random House has given her the title of "Queen of audio and radio drama" for her extensive work in the medium.

Her credits include His Dark Materials, Stuff Happens and The Revenger's Tragedy at the National Theatre; A Streetcar Named Desire (National Theatre Studio); Troilus and Cressida, Julius Caesar, Tamburlaine and The Odyssey (RSC); Sugar Mummies and Breath Boom (Royal Court); Richard II (Globe); Les Liaisons Dangereuses (Donmar Warehouse); Great Expectations (Bristol Old Vic); Blood Wedding (Almeida); Nights at the Circus, The Dispute and Pericles (Lyric Hammersmith); Julius Caesar (The Bridge); Purgatorio (Arcola); The Vagina Monologues (Criterion); Starstruck (Tricycle) and In The Red and Brown Water (Young Vic).

[33] Also in 2021, she was named Cameron Mackintosh Visiting Professor of Contemporary Theatre at St. Catherine's College, University of Oxford.

[43] In May 2023, following the coronation of King Charles III, Andoh stated that the day's proceedings had "gone from the rich diversity of the Abbey to a terribly white balcony".