[2][3] The building was also designated a contributing property to the Sixteenth Street Historic District in 1978.

It is a large and roughly rectangular structure, two stories in height, its exterior finished in Indiana limestone.

The original main building was basically square, with small flanking wings.

[3] The organization's mission is to fund talented individuals so that they can perform basic research for the betterment of mankind without significant constraints.

On April 2, 2021 Carnegie president Eric Isaacs announced that the building has been sold to Qatar for an undisclosed sum.